Genomic profiling of t-cell activation suggests increased sensitivity of memory t cells to cd28 costimulation

HIGHLIGHTS

• who: Dafni A. Glinos from the Open Targets, Wellcome Genome Campus, Hinxton , SA, UK have published the paper: Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation, in the Journal: (JOURNAL)
• what: The authors show that genes involved in cell cycle progression and division are CD28-driven in memory cells but under TCR control in naive cells. Lastly the authors show that CD28-sensitive genes are enriched in GWAS regions associated with immune diseases implicating a role for CD28 in disease development. The study provides important insights into . . .
  

   

  

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