HIGHLIGHTS
SUMMARY
Concerning pharmacodynamics, in_vitro studies have shown that 4,40 -DMAR acts on the monoamine system. More recently, in a mouse in_vivo study, the two DMAR stereoisomeric forms also demonstrated opposite toxicity: (±)trans-4,40 -DMAR did not show toxic effects; conversely, (±)cis-4,40 -DMAR exhibited severe levels of toxicity, including salivation, convulsions, hyperthermia and death, attributable to the serotonin syndrome. RPDsresulted resultedabove above OECD guideline threshold (equal ±up 5%) the RPDs thethe OECD guideline threshold (equal to 45to±45 5%) to up the to con0 -DMAR and at all the concentrations tested for . . .
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