HIGHLIGHTS
- who: Ik Shin Chin from the Published in partnership with CEGMR, King Abdulaziz University have published the research work: Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity, in the Journal: (JOURNAL)
- how: This study of 1751 patients on ICIs identified a genome-wide significant association between a SNP mapping to IL7 rs16906115 Published in partnership with CEGMR King Abdulaziz University 11 and any grade irAE toxicities65. rs16906115 replicates in two independent cohorts and is the first genetic variant associated with irAEs to have been identified using large sample sizes and validation cohorts65.
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