Germline mutations in the dna damage response genes brca1, brca2, bard1 and tp53 in patients with therapy related myeloid neoplasms

HIGHLIGHTS

  • who: Schulz and Eduard from the Division of, University of Graz, Austria have published the research: Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms, in the Journal: (JOURNAL) of 31/Dec/2010
  • what: The authors performed systematic pedigree and mutational analyses on patients with t-MNs seen at a tertiary cancer centre. The study demonstrates that cancer predisposition syndromes are prevalent in patients with t-MNs and can be identified by conventional pedigree analysis as well as systematic mutational screens.
  • how . . .

     

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