Gigyf1 -disturbed igf-1r recycling: a potential contributor to autism spectrum disorder pathogenesis?

HIGHLIGHTS

• who: from the Wenzhou Medical University have published the paper: GIGYF1 -disturbed IGF-1R recycling: a potential contributor to autism spectrum disorder pathogenesis?, in the Journal: (JOURNAL)
• what: The paper shows that inherited GIGYF1 heterozygous likely gene-disruptive (LGD) variants are more common than de novo mutations.
• future: Studies are needed to validate this study . Future analysis of other ASD high-risk genes will be valuable for understanding genetic factors in ASD. Future studies are warranted to analyze the interaction between GIGYF1 and IGF-1R in the Gigyf1-deficient mice to better understand . . .
  

   

  

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