Gip reduces osteoclast activity and improves osteoblast survival in primary human bone cells

HIGHLIGHTS

• who: Significance and colleagues from the Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, Odense C DK-5000, Denmark have published the Article: GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells, in the Journal: (JOURNAL)
• what: Using a GIPR-specific antagonist the authors aimed to assess whether acts directly on primary human osteoclasts and osteoblasts. The studies demonstrated that GIPR is robustly expressed on primary human osteoclasts, increasing during differentiation, and utilizes multiple signaling pathways to reduce osteoclast differentiation and bone resorption . The authors demonstrate that GIP-mediated . . .
  

   

  

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