HIGHLIGHTS
- who: Ethan Roy from the (UNIVERSITY) have published the research: Glial interference: impact of type I interferon in neurodegenerative diseases, in the Journal: (JOURNAL)
SUMMARY
Open Access Glial interference: impact of type I interferon in neurodegenerative diseases Ethan Roy and Wei Cao* revealed an age-dependent accumulation of IRM immediately adjacent to Aβ plaques, underscoring a chronic IFN activation in AD brain. Consequently, ablation of IFN-I receptor gene selectively from neural cells reduces Aβ plaques in a mouse AD model, affirming a feedforward loop whereby plaque-induced inflammation further exacerbates AD pathology . . .
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