HIGHLIGHTS
- who: Gregory P. Takacs and collaborators from the INSERM , Institut Cochin, France Fourth Military Medical University have published the research work: Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+/CX3CR1+ M-MDSCs into the tumor microenvironment in a redundant manner, in the Journal: (JOURNAL)
- what: This study investigated the T_cell suppressive function and chemokine ligand dependency by which CCR2+/CX3CR1+ M-MDSCs traffic into the glioma microenvironment. Using a preclinical glioma model, the authors demonstrate that CCR2+/CX3CR1+ cells are sourced from the bone marrow, suppress both CD4+ and CD8+ T_cells, migrate . . .
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