Globally prevalent pfmdr1 mutations modulate plasmodium falciparum susceptibility to artemisinin-based combination therapies

HIGHLIGHTS

• who: M. Isabel Veiga from the of Microbiology and Immunology, Columbia University Medical Center, Room , HHSC, West, th Street, New York, New York , have published the paper: Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 18/05/2016
• what: This approach has been successfully used to define the role of the resistance mediators pfcrt, k13 and pi4k7,26-28. The authors report its successful use to engineer pfmdr1 N86Y and Y184F mutations in parasite strains that express the two major CQ resistance . . .
  

   

  

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