Glp-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice

HIGHLIGHTS

• who: Carmelo Quarta from the Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg, GermanyUniversity of have published the article: GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice, in the Journal: (JOURNAL) of 15/Nov/2021
• what: The authors report the preclinical pharmacological evaluation of a single molecule conjugate of tesaglitazar covalently attached to a biochemically optimized non-acylated glucagon-like peptide-1 analogue (GLP-1 Aib2 Glu16 CEX Lys40). The authors demonstrate that GLP-1RA/tesaglitazar is comparably efficacious as the pharmacokinetically matched GLP-1RA to promote . . .
  

   

  

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