-glucocerebrosidase deficiency activates an aberrant lysosome-plasma membrane axis responsible for the onset of neurodegeneration

HIGHLIGHTS

• who: Giulia Lunghi et al. from the Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy have published the Article: -Glucocerebrosidase Deficiency Activates an Aberrant Lysosome-Plasma Membrane Axis Responsible for the Onset of Neurodegeneration, in the Journal: Cells 2022, 11, 2343. of 21/06/2022
• what: Based on these premises, the authors focused the analysis on PM DRM obtained from CBEtreated and untreated DA neurons, where the authors observed the accumulation of GlcCer.
• how: In this frame the authors developed two in vitro neuronal models of represented by mouse . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.