HIGHLIGHTS
- who: Xiyu Liu et al. from the DepartmentMedical University, Xi`an, China have published the article: Glucose- and glutamine-dependent bioenergetics sensitize bone mechanoresponse after unloading by modulating osteocyte calcium dynamics, in the Journal: (JOURNAL)
- what: The authors provide mechanistic insight into disuse-induced deterioration of bone mechanosensitivity and a promising therapeutic approach to accelerate bone recovery after long-duration disuse. The authors demonstrate that the capacity of the load-mediated regulation of bone microstructure, mechanical strength, and bone metabolism is compromised in skeletons previously exposed to unloading. The authors provide the first direct evidence . . .
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