Glucose starvation or pyruvate dehydrogenase activation induce a broad, erk5-mediated, metabolic remodeling leading to fatty acid oxidation

HIGHLIGHTS

  • who: Abrar Ul Haq Khan et al. from the Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland have published the research: Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation, in the Journal: Cells 2022, 11, x FOR PEER REVIEW of 14/04/2022
  • what: The authors show that glucose starvation or sustained pyruvate dehydrogenase (PDH) activation by dichloroacetate (DCA) induce large genetic remodeling to propel FAO. The authors show here that different families of enzymes which are essential to perform FAO are regulated by . . .

     

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