Glutamate-induced deregulation of krebs cycle in mitochondrial encephalopathy lactic acidosis syndrome stroke-like episodes (melas) syndrome is alleviated by ketone body exposure

HIGHLIGHTS

• who: Sophie Belal et al. from the Biochemistry and Genetics Department, University Hospital of Angers, Angers, France have published the article: Glutamate-Induced Deregulation of Krebs Cycle in Mitochondrial Encephalopathy Lactic Acidosis Syndrome Stroke-Like Episodes (MELAS) Syndrome Is Alleviated by Ketone Body Exposure, in the Journal: (JOURNAL)
• what: This experiment showed a 58.5% reduction in complex I activity compared to untreated cells, which was associated with a 245% increase in intracellular glutamate concentration, compared to untreated cells . The aim was to identify a metabolic signature and relevant pathways, and ultimately to monitor the . . .
  

   

  

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