Glutamine-expanded ataxin-7 alters tftc/staga recruitment and chromatin structure leading to photoreceptor dysfunction

HIGHLIGHTS

• who: PLoS BIOLOGY et al. from the Institut Physiopathologie Cellulaire et Moléculaire de la Rétine, INSERM, UPMC, Paris, France have published the research work: Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction, in the Journal: (JOURNAL)
• what: The authors show here that complexes purified from SCA7 mice have normal TRRAP GCN5 TAF12 and SPT3 levels and that their histone or nucleosomal acetylation activities are unaffected. Based on the findings , the authors propose that mutant ATXN7, by its incorporation in TFTC-type complexes, deregulates its recruitment, thereby . . .
  

   

  

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