Glycolysis regulates kras plasma membrane localization and function through defined glycosphingolipids

HIGHLIGHTS

  • who: Junchen Liu from the Cell culture and transfection Mardin-Darby canine kidney (MDCK) cells, Gift of DrRobert G. Parton (University of Queensland, Australia) have published the Article: Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids, in the Journal: (JOURNAL) of 17/01/2023
  • what: The authors report an effect of increased glycolytic flux that feeds into glycosphingolipid biosynthesis and is directly linked to KRAS oncogenic function. The authors combine high-resolution imaging and genetic approaches, to show that defined GSLs are essential for the maintenance of KRAS PM localization and KRAS . . .

     

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