Glycolytic-to-oxidative fiber-type switch and mtor signaling activation are early-onset features of sbma muscle modified by high-fat diet

HIGHLIGHTS

• who: Anna Rocchi from the Venetian Institute of Molecular Medicine, Department of Biomedical Science, University of Padova, Padua, Italy have published the article: Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet, in the Journal: (JOURNAL)
• what: The authors show that glycolytic muscles were more severely affected than oxidative muscles in SBMA knock-in mice. atrophy was associated with early-onset progressive glycolytic-to-oxidative fibertype switch.
• future: Investigation is required to address whether altered glycolysis underlies or contributes to . . .
  

   

  

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