Glycotail and flexitail as half-life extension modules for recombinant antibody fragments

HIGHLIGHTS

  • who: Oliver Seifert and Roland E. Kontermann from the Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany have published the research work: GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments, in the Journal: Molecules 2022, 27, 3272. of /2022/
  • what: The authors focused on C-terminal fusions of the GlycoTAIL and FlexiTAILs. The study demonstrated that expression in mammalian cells results in heterogeneous glycosylation as revealed by SDS-PAGE and SEC analysis. To antibody molecules differing in size and valency, the authors provide the first evidence that these . . .

     

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