Grk2 inhibitors, paroxetine and ccg258747, attenuate ige-mediated anaphylaxis but activate mast cells via mrgprx2 and mrgprb2

HIGHLIGHTS

• who: Monica Thapaliya from the Institut National de la Santu00e9 et de la France Ehime University have published the research: GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2, in the Journal: (JOURNAL)
• what: The aim of this study was to determine if paroxetine and CCG258747 inhibit IgE/FceRI-mediated MC degranulation and anaphylaxis.
• future: There has been a previous postulation that SSRIs suppress IgE-ATP positive feedback via purinergic receptors which could be one of the possible mechanisms of action and will be the . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.