Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted ear11

HIGHLIGHTS

  • who: Veera Panova from the (UNIVERSITY) have published the research: Group-2 innate lymphoid cell-dependent regulation of tissue neutrophil migration by alternatively activated macrophage-secreted Ear11, in the Journal: (JOURNAL)
  • what: Exploiting several complementary approaches, including Ear11 overexpression in transgenic mice, Ear11 ablation and exogenous Ear11 administration, the authors demonstrate here that Ear11 is a monocyte- and AAM-secreted regulator of neutrophil homoeostasis and migration.
  • future: This discovery prompts the future investigation of the syntenic human molecules EDN and ECP which may have as yet unappreciated roles in AAM biology and indeed . . .

     

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