Gsk-3β inhibition enhances sorafenib-induced apoptosis in melanoma cell lines*

HIGHLIGHTS

• who: David J. Panka from the bined with the floating, non-adherent cellsPropidium iodide (, ng/ml have published the paper: GSK-3β Inhibition Enhances Sorafenib-induced Apoptosis in Melanoma Cell Lines*, in the Journal: (JOURNAL) of January/11,/2008
• what: In this report, the authors show that sorafenib activates GSK-3␤ in multiple subcellular compartments and that this activation undermines the lethality of the drug. For most of the studies shown, the significance of an apparent difference in mean values for any parameter (e_g the percent of cells staining with propidium iodide) was validated by . . .
  

   

  

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