Gsk3 phosphorylates dynamin-2 to promote glut4 endocytosis in muscle cells

HIGHLIGHTS

• who: Jessica Laiman and colleagues from the of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan have published the research work: GSK3 phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells, in the Journal: (JOURNAL) of 29/03/2023
• what: The authors demonstrate that Dyn2 inhibition by Bin1 is relieved by phosphorylation of Dyn2-PRD by GSK3u03b1, which reduces the binding between the SH3 domain of Bin1 and Dyn2-PRD. Among the putative phosphorylation sites on Dyn2-PRD, the authors focused on Ser848 and Ser856, two serine residues located within the SH3 . . .
  

   

  

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