Guanfacine normalizes the overexpression of presynaptic -2a adrenoceptor signaling and ameliorates neuropathic pain in a chronic animal model of type 1 diabetes

HIGHLIGHTS

  • who: Neha Munawar and collaborators from the Department of Pharmacology and Toxicology, Faculty of Medicine, University have published the article: Guanfacine Normalizes the Overexpression of Presynaptic -2A Adrenoceptor Signaling and Ameliorates Neuropathic Pain in a Chronic Animal Model of Type 1 Diabetes, in the Journal: Pharmaceutics 2022, 14, 2146. of /2022/
  • what: The aim of this study was to investigate the hypothesis that the development of neuropathic pain stems from a defect in 3 of 22 the central noradrenergic system activity in T1DM and chronic administration of guanfacine reverses the defect of the noradrenergic system . . .

     

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