Guanidinylated polymyxins as outer membrane permeabilizers capable of potentiating rifampicin, erythromycin, ceftazidime and aztreonam against gram-negative bacteria

HIGHLIGHTS

  • who: Danzel Marie Ramirez et al. from the Department of Chemistry, University of Manitoba, Winnipeg, MB R T , Canada have published the article: Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria, in the Journal: Antibiotics 2022, 11, x FOR PEER REVIEW Antibiotics 2022, 11, 1277 of /2022/
  • what: This study shows that guanidinylation transforms polymyxins into effective OM permeabilizers capable of potentiating multiple classes of antibiotics against clinically relevant multidrug-resistant (MDR) Gram-negative pathogens.
  • how: The experiment was conducted in triplicate and . . .

     

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