HIGHLIGHTS
- who: Thierry Frebourg from the Department of Genetics, Rouen University Hospital and Inserm, Normandie University, UNIROUEN, Normandy Centre for Genomic and Personalized Medicine, Rouen, France have published the research work: Guidelines for the Li⠍Fraumeni and heritable TP53-related cancer syndromes, in the Journal: (JOURNAL)
SUMMARY
The diversity of clinical presentations associated with germline TP53 alterations justifies the expansion of the LFS concept to a wider cancer predisposition syndrome designated heritable TP53-related cancer (hTP53rc) syndrome. The frequency of presentations without familial cancer history is explained both by the contribution of de novo . . .
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