Gut dysbiosis induces the development of mastitis through a reduction in host anti-inflammatory enzyme activity by endotoxemia

HIGHLIGHTS

  • who: Caijun Zhao from the Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China have published the research work: Gut dysbiosis induces the development of mastitis through a reduction in host anti-inflammatory enzyme activity by endotoxemia, in the Journal: (JOURNAL)
  • what: This study reveals that mastitis cows had marked ruminal microbiota disruption and increased systemic inflammation.
  • how: The authors showed that low-grade LPS exposure induced mastitis through reducing host ALP activity by the TLR4-neuraminidase (Neu)-ALP pathway which further deteriorated E. coli-induced mastitis . . .

     

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