HIGHLIGHTS
SUMMARY
In the HVTN 096 trial, where the impact of the gut microbiota on HIV-specific immune_response to a DNA-prime, poxvirus-boost strategy in human adults was assessed, baseline and vaccine-induced gp41-reactive IgG titers were associated with different microbiota community structures, in terms of richness and composition. Co-occurring bacterial groups, such as Ruminococcaceae, Peptoniphilaceae, and Bacteroidaceae, were associated with vaccine-induced IgG response and inversely correlated with pre-existing gp41 binding IgG antibodies, suggesting that the microbiome may influence the immune_response and vaccine immunogenicity. Evidence emerged from other studies in typhoid . . .
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