HIGHLIGHTS
- who: Rachel Bayley from the Institut University of Birmingham, Birmingham , TT, UK have published the research: H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ, in the Journal: (JOURNAL) of May/19,/2022
- what: The authors demonstrate that RIF1 also physically and functionally interacts with BOD1L and SETD1A, which are required for its recruitment to DSBs. Crucially, the authors show that RIF1 directly binds to methylated H3K4. Since hematopoietic loss of Setd1a blocks B cell development (Tusi et_al, 2015), the authors focused on the role of Bod1l in these processes. STAR+METHODS Detailed methods are . . .
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