Hallmarks of severe covid-19 pathogenesis: a pas de deux between viral and host factors

HIGHLIGHTS

  • who: Roberta Rovito from the Department of Health Sciences, University of Milan, Milan, Italy have published the paper: Hallmarks of Severe COVID-19 Pathogenesis: A Pas de Deux Between Viral and Host Factors, in the Journal: (JOURNAL)
  • what: Though the majority of studies focus on T_cell and antibody responses, perturbations in the B cell compartment associated with COVID-19 severity have been described. Given the severity of the disease, human challenge studies aimed at evaluating disease severity in relation to the initial viral inoculum are lacking; however, several animal studies suggest interesting associations.
 

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