HIGHLIGHTS
- who: Sai Pooja Mahajan from the University of Washington, United States have published the Article: Hallucinating structure-conditioned antibody libraries for target-specific binders, in the Journal: (JOURNAL)
- what: To further select antigen-specific designs, the authors propose a pipeline to virtually screen the hallucinated sequences against a target antigen. The authors show that such targeted exploration of the sequence space enables in silico improvements in binding energies and other desirable antibodyantigen interface metrics such as hydrogen_bonding, shape complementarity and buried surface area at the interface. The authors aim to design sequences that fold into . . .
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