Halogen bonds involved in binding of halogenated ligands by protein kinases

HIGHLIGHTS

• who: Jarosu0142aw Poznau0144ski and collaborators from the Institute of Biochemistry and Biophysics PAS, Warszawa, Poland have published the research work: Halogen bonds involved in binding of halogenated ligands by protein kinases, in the Journal: (JOURNAL)
• what: The foregoing analysis clearly shows that in the tightly packed ATP binding pocket of a protein kinase, due to observed significant differences in geometrical preferences, a pattern of H-bonds cannot a priori be replaced by X-bonds.

SUMMARY

Other options to improve selectivity include non-ATP-competitive inhibitors (Harrison et_al, 2008; Battistutta, 2009; Kirkland . . .

 



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