HIGHLIGHTS
SUMMARY
Previously, the authors have characterized Drosophila HTT homolog (dhtt), which has relatively low homology at the amino_acid level with human HTT. Lastly, when tested with fly models of HD, HAP40 significantly altered the levels of overexpressed human full-length HTT protein, but only mildly modulated neurodegeneration induced by full-length mutant HTT and no effect on mutated HTT exon 1. The homology between CG8134 and HAP40 exists throughout most of the proteins, and are particularly prominent in two ~50 amino_acid (a.a.) long stretches at their N- or C-terminal regions, where there are . . .
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