Haploinsufficiency of cathepsin d leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

HIGHLIGHTS

• who: E-J Bae from the Neuroscience Research InstituteNational University have published the Article: Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates, in the Journal: (JOURNAL)
• what: The authors showed that experimental haploinsufficiency of CTSD resulted in the reduction of lysosomal functions, impaired α-synuclein catabolism, increased α-synuclein secretion and decreased degradation of internalized α-synuclein, leading to increased cell-to-cell transmission of α-synuclein aggregates. The study shows that lysosomal functions could be sensitive to quantities of individual hydrolases. The authors propose a hypothesis that quantitative changes . . .
  

   

  

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