HIGHLIGHTS
SUMMARY
In these processes, the adaptive immune_response (CD4+ and CD8+ T_cell responses, as well as neutralizing antibodies) is significantly more involved than the innate one. HBV-specific CD4+ T_cells instead act by inducing and favoring the persistence of CD8+ T_cell and antibody responses. In chimpanzee models, an early HBV-specific CD4+ T_cell response was predictive of viral clearance, and the depletion of CD4+ T_cells results in HBV persistence. Indeed, early CD4+ T_cell depletion would result in viral persistence, whereas no impact on infection course was demonstrated for CD4+ T_cell depletions obtained six weeks after inoculation . . .
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