HIGHLIGHTS
SUMMARY
HCMV has been shown to perturb the composition of the memory T_cell compartment in numerous independent studies resulting in expansions of CD4+ and CD8+ polyfunctional (capable of secreting different cytokines and cytotoxic functions) HCMV specific T_cells with effector memory and differentiated phenotypes. While the authors did not observe significant effects of age on the magnitude of the HCMV specific T_cell and total IgG responses, there was however a clear defect in the ability of the T_cells from older donors to control HCMV infection and dissemination in a VDA. The link between HCMV infection and . . .
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