Hdac inhibition in vascular endothelial cells regulates the expression of ncrnas

HIGHLIGHTS

  • who: Haloom Rafehi and Assam El-Osta from the Department of Pathology, The University of Melbourne, Parkville, VIC, Australia have published the Article: HDAC Inhibition in Vascular Endothelial Cells Regulates the Expression of ncRNAs, in the Journal: (JOURNAL)
  • what: The authors investigate high throughput sequencing data derived from primary human endothelial cells stimulated with suberanilohydroxamic acid (SAHA) and Trichostatin A (TSA). The authors show that EP300 target genes are subject to histone deacetylation at their promoter following inhibition. The authors show that regulate the expression of ncRNA by complex and class-specific epigenetic mechanisms. The . . .

     

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