HIGHLIGHTS
- who: Y Huang from the Shanghai Key Laboratory Tongji University, Shanghai, PR China have published the research work: HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation, in the Journal: (JOURNAL)
- how: Showed that knockdown of HDAC1 significantly inhibited cell proliferation . The results showed that HDAC2 knockdown mainly induces apoptosis of leukemia cells whereas HDAC3 and HDAC8 have no effect on the proliferation of leukemia cells which are different from HDAC1 function (Supplementary Figure S3B and S3D). Showed that Sp1 expression was reduced and acetyl-Sp1 level was elevated upon mocetinostat treatment (Supplementary . . .
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