Hdac1 inhibition by ms-275 in mesothelial cells limits cellular invasion and promotes mmt reversal

HIGHLIGHTS

• who: Lucia Rossi from the Effluent-derived MCs were isolated from , clinically stable PD patients as described previously Baseline clinical data from these patients are reported in Table, . MCs from PD effluents express the standard mesothelial markers intercellular adhesion molecule (ICAM), and cytokeratins, although at lower levels than healthy HPMCs. MC cultures are negative for the endothelial marker , and the pan-leukocyte marker , , . Effluent-derived MCs were cultured in Earle`s , supplemented with, % FBS (GIBCO Life Technology, Monza, Italy) and antibiotics. To enhance EMT-like features, MCs were treated with TGFu03b2, (, ng/ml) as described previously19, . The . . .
  

   

  

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