Hdc downregulation induced by chronic stress promotes ovarian cancer progression via the il-6/stat3/s100a9 pathway

HIGHLIGHTS

• What: The authors noted that CUMS promoted tumor growth in a successfully established comorbidity of ovarian cancer and depression in_vivo mouse model, consistent with previous studies (Thaker et_al, 2006), and provided a novel therapeutic target. The authors provide a novel mechanism by which chronic stress enhances ovarian cancer progression: chronic stress-induced HDC downregulation and alterations in histidine metabolism serve as critical factors regulating cancer progression. This study provides important insights into the effects of chronic stress on animal behavior, physiology, cellular functions, and immune system, as well as the underlying molecular mechanisms.
• Who: . and . . .
  

   

  

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