Heat-inactivated factor b inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von willebrand factor strings

HIGHLIGHTS

• who: Nancy A. Turner from the DepartmentRice University have published the research: Heat-inactivated Factor B inhibits alternative pathway fluid-phase activation and convertase formation on endothelial cell-secreted ultra-large von Willebrand factor strings, in the Journal: Scientific Reports Scientific Reports
• what: The authors propose that HFB is resistant to cleavage by FD, and therefore, C3b-HFB complexes do not produce Bb or generate Ba.
• how: In parallel verification experiments the antibody used to detect FB and Ba proteins was tested for linear detection. In this study Western blot analysis was used . . .
  

   

  

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