HIGHLIGHTS
- who: C K Yang from the (UNIVERSITY) have published the Article: Heat shock protein 90 regulates necroptosis by modulating multiple signaling effectors, in the Journal: (JOURNAL)
- how: A fascinating observation was made by both the Murphy9 and Zhang10 research groups HSP90 modulates MLKL stability and function in the necroptosis pathway.
SUMMARY
Upon phosphorylation, MLKL forms oligomers and translocates to the plasma_membrane to induce necrotic cell death. RHIM-containing proteins such as TRIF, DAI, and ICP6 are known to activate RIP3.5 Thus, RIP3 is considered to be a central signaling molecule . . .
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