HIGHLIGHTS
- who: Katrin Schru00f6er and colleagues from the Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany have published the Article: HEHR: Homing Endonuclease-Mediated Homologous Recombination for Efficient Adenovirus Genome Engineering, in the Journal: Genes 2022, 13, 2129. of /2022/
- what: The work described here was encouraged by the fact that a doublestrand break generated by CRISPR/Cas9 can highly increase the homologous recombination efficiencies in mammalian genomes . With Detailed Protocol Since the adenovirus genome engineering with the original selection marker (SM) was already described previously , in the current protocol the authors focused on the . . .
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