HIGHLIGHTS
- who: Ernest Y. Lee from the University of have published the research work: Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors examine the structures of immunologically active complexes formed between DNA and three prototypical ɑ-helical AMPs (melittin, LL37, and buforin) and related mutants from the perspective of Janus self-assembly using a combination of synchrotron small-angle X-ray scattering (SAXS) and molecular modeling. Using AMPs melittin, LL37, and buforin, the authors show how AaH hydrophobicity impacts protofibril self-assembly . . .
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