HIGHLIGHTS
- who: Viktoria Plackoska from the University of Salford, United Kingdom have published the research: Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression, in the Journal: (JOURNAL)
- what: In this study tumor specific overexpression of PDGF-BB in the T241 fibrosarcoma and LLC lung carcinoma cells subcutaneously inoculated into mouse models was shown to induce erythropoietin production by stromal cells, stimulating extramedullary erythropoiesis in both spleen and liver, and promoting angiogenesis and tumor growth . however impair DC infiltration and activation, and induce immunosuppressive DC states .
- future: The exact . . .
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