Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology

HIGHLIGHTS

• who: Youqi Tao from the InstitutTong University Shanghai, China have published the research work: Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors used cryo-EM to determine the atomic structures of α-syn fibrils that were formed in the presence of heparin and comparatively in the absence of heparin. The work provides mechanistic understanding for the impact of heparin on the structure and pathology of α-syn fibrils, and highlights the potential of biological polymers in the determination of fibril polymorphs. The authors showed . . .
  

   

  

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