HIGHLIGHTS
- who: Victor H. Villar from the (UNIVERSITY) have published the Article: Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer, in the Journal: (JOURNAL) of 18/02/2022
- what: The authors show that mammalian GS uses glutamate and methylamine to produce a methylated glutamine analog, N5-methylglutamine. The authors show that urine levels of Nu00ad5u00ad u00ad-mu00adetu00adhyu00adlgu00adlutamine correlate with tumor burden and GS expression in a u03b2-catenin-driven model of liver cancer, highlighting the translational potential of this uncharacterized metabolite. The authors demonstrated that GS accepts methylamine as a substrate for the ATP . . .
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