Hepatic ros mediated macrophage activation is responsible for irinotecan induced liver injury

HIGHLIGHTS

• who: Bohao Liu et al. from the The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, Hunan Normal University School of Medicine, Changsha, China have published the research: Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury, in the Journal: Cells 2022, 3791 of /2022/
• what: The authors investigated the role of macrophages in irinotecan-induced liver injury both in_vitro and in_vivo.
• how: In vitro data indicated that irinotecan induced intracellular production in primary hepatocyte and upregulating of toll-like receptor (TLRs) family expression in macrophages . . .
  

   

  

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