HIGHLIGHTS
- What: The authors used this culture system established for hepatic progenitor cells to culture adult mouse hepatocytes and examine the dynamics and mechanisms of hepatocyte dedifferentiation and the differentiation potential of cells dedifferentiated from hepatocytes. To assess the relationship among various types of cells analyzed in this study, the authors investigated the global gene_expression profiles in these cells and performed principal component analysis (PCA) (Fig 7c).
- Who: Shizuka Miura from the Mice C BL/, (Clea Japan, Tokyo, Japan), Alb-Cre (The Jackson Laboratory, Bar Harbor, ME)41, Alb-Cre, (a gift from DrsPierre Chambon and . . .
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