Hepatoprotective activity of lignin-derived polyphenols dereplicated using high-resolution mass spectrometry, in vivo experiments, and deep learning

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SUMMARY

    According to a recent analysis, acute and chronic liver diseases remain a significant public health threat in Europe with more than 1 billion affected people, with increasing incidence and prevalence of these diseases in industrialized countries. Most of the papers published on the biological activity of complex mixtures are related to recording the biological response in experiments in_vitro and in_vivo, while their molecular mechanism of action remains unknown. Based on the data obtained in silico, an in_vivo experiment on the evaluation of the hepatoprotective activity of BP-Cx-1 and its fraction was carried . . .

     

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