Her2/neu- and tak1-mediated up-regulation of the transforming growth factor β inhibitor smad7 via the ets protein er81*

HIGHLIGHTS

• who: Sean C. Dowdy from the (UNIVERSITY) have published the research work: HER2/Neu- and TAK1-mediated Up-regulation of the Transforming Growth Factor β Inhibitor Smad7 via the ETS Protein ER81*, in the Journal: (JOURNAL) of August/18,/2003
• what: In this report the authors show that the oncoprotein HER2/Neu is able to collaborate with the ETS transcription factor ER81 to activate Smad7 transcription in breast, endometrial, and ovarian cancer cell lines. The authors show that Smad7 activation involves the processing of signals from HER2/Neu to ER81 via the ERK mitogen-activated protein . . .
  

   

  

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